papers | Brain Modulation Lab

Lateralized and region-specific thalamic processing of lexical status during reading aloud

Wang D, Lipski WJ, Bush A, Chrabaszcz A, Dastolfo-Hromack C, Dickey MW, Fiez JA, Richardson RM. JNeurosci. 2022.

Hyperdirect connectivity of opercular speech networks to the subthalamic nucleus

Jorge A, Lipski WJ, Wang D, Crammond DJ, Turner RS, Richardson RM. Cell Reports. 2022.

Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings

Bush A, Chrabaszcz A, Peterson V, Saravanan V, Dastolfo-Hromack C, Lipski WJ, Richardson RM. NeuroImage. 2021.

Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech

C Dastolfo-Hromack, A Bush, A Chrabaszcz, A Alhourani, W Lipski, D Wang, D J Crammond, S Shaiman, M W Dickey, L L Holt, R S Turner, J A Fiez, RM Richardson. Cerebral Cortex. 2021.

Simultaneously recorded subthalamic and cortical LFPs reveal different lexicality effects during reading aloud

Chrabaszcz A, Wang D, Lipski WJ, Bush A, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. J Neurolinguistics. 2021.

ECoG During Deep Brain Stimulation Surgery: Safety Experience From 4 Centers Within the NINDS Research Opportunities in Human Consortium

Sisterson ND, Carlson AA, Rutishauser U, Mamelak AN, Flagg M, Pouratian N, Salimpour Y, Anderson WS, Richardson RM. Neurosurgery. 2021.

Fischer P, Lipski WJ, Neumann WJ, Turner RS, Fries P, Brown P, Richardson RM. eLife. 2020.

Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction

Alhourani A, Korzeniewska, Wozny TA, Lipski WJ, Kondylis ED, Ghuman AS, Crone NE, Crammond DJ, Turner RS, Richardson RM. Cerebral Cortex. 2020.

Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production

Chrabaszcz A, Neumann WJ, Stretcu O, Lipski WJ, Bush A, Dastolfo-Hromack C, Wang D, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. Journal of Neuroscience. 2019.

Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production

Lipski WJ, Alhourani A, Pirnia T, Jones PW, Dastolfo-Hromack C, Helou LB, Crammond DJ, Shaiman S, Dickey MW, Holt LL, Turner RS, Fiez JA, Richardson RM. Journal of Neuroscience. 2018.

Dynamics of Human Subthalamic Neuron Phase-locking to Motor and Sensory Cortical Oscillations During Movement

Lipski WJ, Wozny TA, Alhourani A, Kondylis E, Turner RS, Crammond DJ, Richardson RM. Journal of Neurophysiology. 2017.

Kondylis ED, Randazzo MJ, Alhourani A, Lipski WJ, Wozny TA, Ghuman AS, Turner RS, Crammond DJ, Richardson RM. Brain. 2016.

Three-dimensional Localization of Cortical Electrodes in Deep Brain Stimulation Surgery from Intraoperative Fluoroscopy

Randazzo MJ, Kondylis ED, Alhourani A, Wozny TA, Lipski WJ, Crammond DJ, Richardson RM. Neuroimage. 2016.

Epilepsy

Deep net detection and onset prediction of electrographic seizure patterns in responsive neurostimulation

Peterson V, Kokkinos V, Ferrante E, Walton A, Merk T, Hadanny A, Saravanan V, Sisterson N, Zaher N, Urban A, Richardson RM. Epilepsia. 2023.

Closed-loop brain stimulation and paradigm shifts in epilepsy surgery

Richardson RM. Neurologic Clinics. 2022.

Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: Initial case series

Sisterson ND, Kokkinos V, Urban A, Li N, Richardson RM. J Neurology Neurosurgery Psychiatry. 2022.

Hippocampal spindles and barques are normal intracranial electroencephalographic entities

Kokkinos V, Hussein H, Frauscher B, Simon M, Urban A, Bush A, Bagić AI, Richardson RM. Clinical Neurophysiology. 2021.

Intracranial monitoring contributes to seizure freedom for temporal lobectomy patients with non-concordant pre-operative data

Sokolov E, Sisterson ND, Hussein H, Plummer C, Corson D, Antony AR, Mettenburg J, Ghearing G, Pan J, Urban A, Bagić A, Richardson RM, Kokkinos V. Epilepsia Open. 2021.

Extrapial Hippocampal Resection in Anterior Temporal Lobectomy: Technical Description and Clinical Outcomes in a 62-Patient Case Series

Hussein H, Kokkinos V, Sisterson ND, Modo M, Richardson RM. Oper Neurosurg. 2021.

Expert-Level Intracranial Electroencephalogram Ictal Pattern Detection by a Deep Learning Neural Network
Constantino AC, Sisterson ND, Zaher N, Urban A, Richardson RM, Kokkinos V. Frontiers in Neurology. 2021.

Quantifying a frequency modulation response biomarker in responsive neurostimulation

Venkatesh P, Sneider D, Danish M, Sisterson ND, Zaher N, Urban A, Grover P, Richardson RM, Kokkinos V. J Neural Eng. 2021.

Ictal Onset Signatures Predict Favorable Outcomes of Laser Thermal Ablation for Mesial Temporal Lobe Epilepsy

Zaher N, Urban A, Antony A, Plummer C, Bagic A, Richardson RM, Kokkinos V. Frontiers in Neurology. 2020.

Ex Vivo Mesoscopic Diffusion MRI Correlates with Seizure Frequency in Patients with Uncontrolled Mesial Temporal Lobe Epilepsy

Ke J, Foley LM, Hitchens TK, Richardson RM, Modo M. Human Brain Mapping. 2020.

Mesoscale Diffusion Magnetic Resonance Imagine of the Ex Vivo Human Hippocampus

Ly M, Foley L, Manivannan A, Hitchens TK, Richardson RM, Modo M. Human Brain Mapping. 2020.

Interpretation of the Intracranial Stereoelectroencephalography Signal

Kokkinos V. Neurosurgery Clinics. 2020.

Neuromodulation of Epilepsy Networks

Sisterson ND, Kokkinos V. Neurosurgery Clinics. 2020.

Decision Making in Epilepsy Surgery

Richardson RM. Neurosurgery Clinics. 2020.

The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity

Kokkinos V, Richardson RM, Urban A. Frontiers in Human Neuroscience. 2020.

Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy

Kokkinos V, Urban A, Sisterson N, Li N, Corson D, Richardson RM. Neurosurgery. 2020.

A Rational Approach to Understanding and Evaluating Responsive Neurostimulation

Sisterson ND, Wozny TA, Kokkinos V, Bagic A, Urban AP, Richardson RM. Neuroinformatics. 2020.

GABA Bouton Subpopulations in the Human Dentate Gyrus Are Differentially Altered in Mesial Temporal Lobe Epilepsy

Alhourani A, Fish KN, Wozny TA, Sudhakar V, Hamilton RL, Richardson RM. J Neurophysiol. 2019.

The Intracranial Correlate of the 14&6/sec Positive Spikes Normal Scalp EEG Variant

Kokkinos V, Zaher N, Antony A, Bagić A, Richardson RM, Urban A. Clin Neurophysiol. 2019.

Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy

Kokkinos V, Sisterson ND, Wozny TA, Richardson RM. JAMA Neurology. 2019.

Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine

Sisterson ND, Wozny TA, Kokkinos V, Constantino A, Richardson RM. Neurotherapeutics. 2019.

Effects of Hippocampal Low-frequency Stimulation in Idiopathic Non-human Primate Epilepsy Assessed via a Remote-sensing-enabled Neurostimulator

Wozny TA, Lipski WJ, Alhourani A, Kondylis ED, Antony A, Richardson RM. Experimental Neurology. 2017.

Detection of Aberrant Hippocampal Mossy Fiber Connections: Ex Vivo Mesoscale Diffusion MRI and Microtractography with Histological Validation

Modo M, Hitchens TK, Liu JR, Richardson RM. Humain Brain Mapping. 2016.

Short-term Neurocognitive Outcomes Following Anterior Temporal Lobectomy

Lee PS, Pardini J, Hendrickson R, Destefino V, Popescu A, Ghearing G, Antony A, Pan J, Bajic A, Wagner D, Richardson RM. Epilepsy and Behavior. 2016.

Sensing-enabled Hippocampal Deep Brain Stimulation in Idiopathic Nonhuman Primate Epilepsy

Lipski WJ, DeStefino VJ, Stanslaski SR, Antony AR, Crammond DJ, Cameron JL, Richardson RM. Journal of Neurophysiology. 2015.

Detection of High-frequency Oscillations by Hybrid Depth Electrodes in Standard Clinical Intracranial EEG Recordings

Kondylis ED, Wozny TA, Lipski WJ, Popescu A, DeStefino VJ, Esmaeili B, Raghu VK, Bagic A, Richardson RM. Frontiers in Neurology. 2014.

Movement Disorders

Biophysical Principles and Computational Modeling of Deep Brain Stimulation

Ng PR, Bush A, Vissani M, McIntyre CC, Richardson RM. Neuromodulation. 2024.

Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

Hollunder B, Ostrem JL, Sahin IA, Rajamani N, Oxenford S, Butenko K, Neudorfer C, Reinhardt P, Zvarova P, Polosan M, Akram H, Vissani M, Zhang C, Sun B, Navratil P,

Reich MM, Volkmann J, Yeh FC, Baldermann JC, Dembek TA, Visser-Vandewalle V, Alho EJL, Franceschini PR, Nanda P, Finke C, Kühn AA, Dougherty DD, Richardson RM,

Bergman H, DeLong MR, Mazzoni A, Romito LM, Tyagi H, Zrinzo L, Joyce EM, Chabardes S, Starr PA, Li N, Horn A. Nature Neuroscience. 2024.

The role of the motor thalamus in deep brain stimulation for essential tremor

Neudorfer C, Kultas-Ilinsky K, Ilinsky I, Paschen S, Helmers AK, Cosgrove GR, Richardson RM, Horn A, Deuschl G. Neurotherapeutics. 2024.

A spatio-spectral approach for movement decoding from cortical and subcortical recordings in patients with Parkinson's disease

Peterson V, Merk T, Bush A, Nikulin V, Kühn AA, Neumann WJ, Richardson RM. Experimental Neurology. 2023.

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

Merk T, Peterson V, Lipski W, Blankertz B, Turner RS, Li N, Horn A, Kühn AK, Richardson RM, Neumann WJ. eLife. 2022.

Machine Learning Based Brain Signal Decoding for Intelligent Adaptive Deep Brain Stimulation

Merk T, Peterson V, Köhlera R, Haufec S, Richardson RM, Neumann. WJ. Experimental Neurology. 2022.

Depression History Modulates Effects of Subthalamic Nucleus Topography on Neuropsychological Outcomes of Deep Brain Stimulation for Parkinson’s Disease

Kratter IH, Jorge A, Feyder MT, Whiteman AC, Chang Y, Henry LC, Karp JF, Richardson RM. Translational Psychiatry. 2022.

Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation

Merk T, Peterson V, Köhler R, Haufe S, Richardson RM, Neumann WJ. Exp Neurol. 2022.

Deep Brain Stimulation for Parkinson's Disease Induces Spontaneous Cortical Hypersynchrony In Extended Motor and Cognitive Networks

Wang MB, Boring MJ, Ward MJ, Richardson RM, Ghuman AS. Cereb Cortex. 2022.

Lateralized Effect of Thalamic Deep Brain Stimulation Location on Verbal Abstraction

Wang D, Jorge A, Lipski WJ, Kratter IH, Henry LC, Richardson RM. Mov Disord. 2021.

Association of Preoperative Visual Hallucinations With Cognitive Decline After Deep Brain Stimulation for Parkinson's Disease

Kratter IH, Karp JF, Chang YF, Whiteman AC, Feyder MT, Jorge A, Richardson RM, Henry LC. J Neuropsychiatry Clin Neurosci. 2020.

Anterior Sensorimotor Subthalamuc Nucleus Stimulation is Associated With Improved Voice Function

Jorge A, Dastolfo-Hromack C, Lipski WJ, Kratter IH, Smith LJ, Gartner-Schmidt JL, Richardson RM. Neurosurgery. 2020.

Robotic-Assisted Stereotaxy for Deep Brain Stimulation Lead Implantation in Awake Patients

Faraji AH, Kokkinos V, Sweat JC, Crammond DJ, Richardson RM. Operative Neurosurgery. 2020.

Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders

Neumann WJ, Turner RS, Blankertz B, Mitchell T, Kühn AA, Richardson RM. Neurotherapeutics. 2019.

Outcomes of Interventional-MRI Versus Microelectrode Recording-Guided Subthalamic Deep Brain Stimulation

Lee PS, Weiner GM, Corson D, Kappel J, Chang Y, Suski VR, Berman SB, Homayoun H, Van Laar AD, Crammond DJ, Richardson RM. Frontiers in Neurology. 2018.

Network Effects of Deep Brain Stimulation

Alhourani A, McDowell MM, Randazzo MJ, Wozny TA, Kondylis ED, Lipski WJ, Beck S, Karp JF, Ghuman AS, Richardson RM. Journal of Neurophysiology. 2015.

Psychiatric Neurosurgery

Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites

Meyer GM, Hollunder B, Li N, Butenko K, Dembek TA, Hart L, Nombela C, Mosley P, Akram H, Acevedo N, Borron BM, Chou T, Castaño Montoya JP, Strange B,

Barcia JA, Tyagi H, Castle DJ, Smith AH, Choi KS, Kopell BH, Mayberg HS, Sheth SA, Goodman WK, Leentjens AFG, Richardson RM, Rossell SL, Bosanac P,

Cosgrove GR, Kuhn J, Visser-Vandewalle V, Figee M, Dougherty DD, Siddiqi SH, Zrinzo L, Joyce E, Baldermann JC, Fox MD, Neudorfer C, Horn A. Biological Psychiatry. 2024.

Toward Closed-Loop Intracranial Neurostimulation in Obsessive-Compulsive Disorder

Vissani M, Nanda P, Bush A, Neudorfer C, Dougherty D, Richardson RM. Biological Psychiatry. 2022.

Cognitive Neuroscience Collaborations

A new paradigm for investigating real-world social behavior and its neural underpinnings.

Alreja A, Ward MJ, Ma Q, Russ BE, Bickel S, Van Wouwe NC, González-Martínez JA, Neimat JS, Abel TJ, Bagić A, Parker LS, Richardson RM, Schroeder CE, Morency LP, Ghuman AS. Behav Res Methods. 2023.

Intracranial Electroencephalography and Deep Neural Networks Reveal Shared Substrates for Representations of Face Identity and Expressions

Schwartz E, Alreja A, Richardson RM, Ghuman A, Anzellotti S. J Neurosci. 2023

Multiple adjoining word- and face-selective regions in ventral temporal cortex exhibit distinct dynamics

Boring MJ, Silson EH, Ward MJ, Richardson RM, Fiez JA, Baker CI, Ghuman AS. Journal of Neuroscience. 2021.

Endogenous Activity Modulates Stimulus and Circuit-Specific Neural Tuning and Predicts Perceptual Behavior

Li Y, Ward MJ, Richardson RM, G'Sell M, Ghuman AS. Nature Communications. 2020.

Posterior Fusiform and Midfusiform Contribute to Distinct Stages of Facial Expression Processing

Li Y, Richardson RM, Ghuman AS. Cerebral Cortex. 2018.

Multi-Connection Pattern Analysis: Decoding the Representational Content of Neural Communication

Li Y, Richardson RM, Ghuman AS. Neuroimage. 2017.

Associative Experiential Phenomena Result from Stimulating Left Ventromedial Temporal Cortex

Aminoff E; Li Y; Pyles JA; Ward MJ; Richardson RM; Ghuman AS. Cortex. 2016.

Decoding and Disrupting Left Mid-fusiform Gyrus Activity During Word Reading

Hirshorn EA , Li Y, Ward MJ, Richardson RM, Fiez J, Ghuman AS. PNAS. 2016.

Dynamic Encoding of Face Information in the Human Fusiform Gyrus

Ghuman AS, Brunet NM, Li Y, Konecky RO, Pyles JA, Walls SA, Destefino V, Wang W, Richardson RM. Nature Communications. 2014.

Gene Therapy Collaborations

Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial

Christine CW, Richardson RM, Van Laar AD, Thompson ME, Fine EM, Khwaja OS, Li C, Liang GS, Meier A, Roberts EW, Pfau ML, Rodman JR, Bankiewicz KS, Larson PS. Neurology. 2022..

Data-driven evolution of neurosurgical gene therapy delivery in Parkinson's disease

Richardson RM, Bankiewicz KS, Christine CW, Van Laar AD, Gross RE, Lonser R, Factor SA, Kostyk SK, Kells AP, Ravina B, Larson PS. J Neurology Neurosurgery Psychiatry. 2020.

Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease

Nutt JG, Curtze C, Hiller A, Anderson S, Larson PS, Van Laar AD, Richardson RM, Thompson ME, Sedkov A, Leinonen M, Ravina B, Bankiewicz KS, Christine CW. Mov Disord. 2020

Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease

Christine CW, Bankiewicz KS, Van Laar AD, Richardson RM, Ravina B, Kells AP, Boot B, Martin AJ, Nutt J, Thompson ME, Larson PS. Ann Neurol. 2019.

Gene Therapy for Neurodegenerative Diseases

Sudhakar V, Richardson RM. Neurotherapeutics. 2019.

Gene Therapy for Parkinson's Disease

Sudhakar V, Richardson RM. Prog Neurol Surg. 2018.

Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain

Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS. Stereotact Funct Neurosurg. 2011.

Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease

Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. Mol Ther. 2011.