Commentary in Brain on stereo-EEG-guided thalamic neurostimulation

In a commentary in Brain, “Thalamic stereo-EEG optimizes neurostimulation therapy,” Dr. Richardson argues that hypothesis-driven thalamic stereo-EEG should be part of routine clinical care for patients with drug-resistant epilepsy who are candidates for neurostimulation. Because sensing-enabled devices can deliver effective therapy when applied to the appropriate seizure network, identifying optimal recording and stimulation sites through thalamic sampling becomes essential rather than merely investigational. Thalamic SEEG can establish the timing of thalamic involvement relative to cortical seizure onset, helping guide whether a cortico-cortical, thalamocortical, or bilateral thalamic strategy will work best, while maintaining the strong safety profile shown across centers. Read it: https://doi.org/10.1093/brain/awaf481