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We are a human systems neuroscience lab studying brain electrophysiology and behavior in patients undergoing surgery for epilepsy, movement disorders, and psychiatric disease. The goal of our work is to facilitate the development and optimization of electrical and biological brain modulation therapies, by filling critical gaps in our understanding of human brain function.  



Basal Ganglia-Cortical Dynamics in Human Behavior 

Intraoperatively, we collect simultaneously recorded cortical ECoG, subcortical MER/LFP, and behavioral data to study interactions between the cortex and basal ganglia that encode specific components of motor control.


STN and STN-Cortical Coding of Speech Production

BRAIN Initiative U01

Cortical-Basal Ganglia Speech Networks

BRAIN Initiative U01


Deep Neural Network Approaches for Closed-loop DBS

CRNCS in collaboration with ICNeuromodulation Neumann Group - Charité Universitätsmedizin Berlin

Closed-Loop Brain Stimulation for Epilepsy

The lab's initial work in brain stimulation for epilepsy involved sensing-enabled DBS (PC+S and RC+S) in a nonhuman primate with idiopathic epilepsy. Subsequently, in order to better understand data recorded during responsive neurostimulation in our epilepsy patients, we built BRAINStim, a platform for Biophysically Rational Analysis and Informed Stimulation.

Electrographic Seizure Pattern Modulation Biomarkers in Responsive Neurostimulation for Epilepsy

NINDS Biomarkers R61

Language Processing 

In this project led by Ev Fedorenko, we are collaborating to study neural responses to language stimuli using intracranial recordings, in combination with the recent advances in computational neuroscience and machine learning, in a quest to understand human linguistic ability.

Computational Neuroscience of Language Processing in the Human Brain

BRAIN Initiative U01


Mapping the Olfactory Perception Network

With funding from Lawnboy Ventures, we are using intracranial LFP recordings to map the electrophysiological correlates of odor perception, with a goal of defining network signatures of odor categories that can be recapitulated via electrical stimulation. The goal of this project is to development an olfactory prosthesis for patients with anosmia. 

Clinical Innovation in Functional Neurosurgery​

The lab's resources, including surgical databases, are leveraged to innovate and advance neurosurgical strategies and technical approaches to better treat epilepsy, movement disorders, and other brain diseases.


Major technological and scientific advances have opened a new era in neurosurgical therapies for people with epilepsy, movement, and psychiatric disorders. These invasive surgical procedures provide the unique ability to record and stimulate neuronal populations in precise brain regions, offering groundbreaking opportunities to explore how our brains perform a wide array of cognitive functions. To optimize these opportunities, Mass General Department of Neurosurgery and MIT Brain and Cognitive Sciences developed the InBRAIN (Intracranial Brain Recording, Analysis, and Intelligent Neuromodulation) Collaboration.


about our logo:

brain on holiday was created by the Italian illustrator Alberto Ruggieri, who generously granted permission for its use by the Brain Modulation Lab.

For other examples of Mr. Ruggieri's work, visit:

want to help sustain our work?

Please direct philanthropic inquiries to Caroline Neely, Brain Modulation Lab Project Manager:  

we're located on the MGH campus, a ten-minute walk from MIT:

Thier Building, 4th floor

Massachusetts General Hospital

50 Blossom St.
Boston, MA 02114

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