BRAIN MODULATION LAB

 

HUMAN SYSTEMS NEUROSCIENCE

The Brain Modulation Lab was founded at the University of Pittsburgh in 2011 and moved to the MGH in 2019. We are a human systems neuroscience lab studying brain electrophysiology and behavior in patients undergoing surgery for epilepsy, movement disorders, and psychiatric disease. The goal of our work is to facilitate the development and optimization of electrical and biological brain modulation therapies, by filling critical gaps in our understanding of human brain function.  

FACULTY SCIENTISTS
Vasileios Kokkinos, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School

Alan Bush, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School

Varun Saravanan, PhD

Data Scientist

MGH-MIT inBRAIN Collaboration 

CONTRIBUTING SCIENTISTS

Victoria Peterson, PhD

Harvard Research Fellow

Brain Modulation Lab

Ashley Walton, PhD

Postdoctoral fellow

Cognitive Science Program, Dartmouth

Nathan Sisterson, MD

Neurosurgery Resident, MGH

STAFF

Irene Lerman, MS

Clinical Research Coordinator

 

Sonika Agarwal, BS

Research Coordinator

CLINICAL SUPPORT
Nora Daly, MSHS, PA-C

Physician Assistant

MGH Functional Neurosurgery

AREAS OF INVESTIGATION

Basal Ganglia-Cortical Dynamics in Human Behavior 

Intraoperatively, we collect simultaneously recorded cortical ECoG, subcortical MER/LFP, and behavioral data to study interactions between the cortex and basal ganglia that encode specific components of motor control.

 

BRAIN Initiative-funded Project:

Closed-Loop DBS for Parkinson's Disease

BRAIN Initiative-funded Project:

in collaboration with ICNeuromodulation Neumann Group (Charité Universitätsmedizin Berlin)

Brain Stimulation for Epilepsy

The lab's initial work involved sensing-enabled DBS (PC+S and RC+S) in a nonhuman primate with idiopathic epilepsy. Subsequently, in order to better understand data recorded during responsive neurostimulation in our epilepsy patients, we built BRAINStim, a platform for Biophysically Rational Analysis and Informed Stimulation.

 

Thier Building, 4th floor

Massachusetts General Hospital

50 Blossom St.
Boston, MA 02114