Lab Wiki




The Brain Modulation Lab was founded at the University of Pittsburgh in 2011 and moved to the MGH in 2019. We are a human systems neuroscience lab studying brain electrophysiology and behavior in patients undergoing surgery for epilepsy, movement disorders, and psychiatric disease. The goal of our work is to facilitate the development and optimization of electrical and biological brain modulation therapies, by filling critical gaps in our understanding of human brain function.  

Vasileios Kokkinos, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School

Alan Bush, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School


Varun Saravanan, PhD

Data Scientist

MGH-MIT inBRAIN Collaboration 

Victoria Peterson, PhD

Harvard Research Fellow

Brain Modulation Lab

Ashley Walton, PhD

Postdoctoral fellow

Cognitive Science Program, Dartmouth

Nathan Sisterson, MD

Neurosurgery Resident, MGH


Sonika Agarwal, BS

Research Coordinator

Nora Daly, MSHS, PA-C

Physician Assistant

MGH Functional Neurosurgery


Basal Ganglia-Cortical Dynamics in Human Behavior 

Intraoperatively, we collect simultaneously recorded cortical ECoG, subcortical MER/LFP, and behavioral data to study interactions between the cortex and basal ganglia that encode specific components of motor control.


STN and STN-Cortical Coding of Speech Production

BRAIN Initiative

Cortical-Basal Ganglia Speech Networks

BRAIN Initiative


Deep Neural Network Approaches for Closed-loop DBS

CRNCS in collaboration with ICNeuromodulation Neumann Group - Charité Universitätsmedizin Berlin

Closed-Loop Brain Stimulation for Epilepsy

The lab's initial work in brain stimulation for epilepsy involved sensing-enabled DBS (PC+S and RC+S) in a nonhuman primate with idiopathic epilepsy. Subsequently, in order to better understand data recorded during responsive neurostimulation in our epilepsy patients, we built BRAINStim, a platform for Biophysically Rational Analysis and Informed Stimulation.

Clinical Innovation in Functional Neurosurgery

The lab's resources, including surgical databases, are leveraged to innovate and advance neurosurgical strategies and technical approaches to better treat epilepsy, movement disorders, and other brain diseases.



brain on holiday was created by the Italian illustrator Alberto Ruggieri, who generously granted permission for its use by the Brain Modulation Lab.

For other examples of Mr. Ruggieri's work, visit:

Thier Building, 4th floor

Massachusetts General Hospital

50 Blossom St.
Boston, MA 02114