BRAIN MODULATION LAB

 

HUMAN SYSTEMS NEUROSCIENCE

The Brain Modulation Lab was founded at the University of Pittsburgh in 2011 and moved to the MGH in 2019. We are a human systems neuroscience lab studying brain electrophysiology and behavior in patients undergoing surgery for epilepsy, movement disorders, and psychiatric disease. The goal of our work is to facilitate the development and optimization of electrical and biological brain modulation therapies, by filling critical gaps in our understanding of human brain function.  

FACULTY AND STAFF
Vasileios Kokkinos, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School

Alan Bush, PhD

Instructor in Neurosurgery, MGH

Harvard Medical School

Varun Saravanan, PhD

Data Scientist

Irene Lerman, MS

Clinical Research Coordinator

 

Sonika Agarwal, BS

Research Coordinator 

CONTRIBUTING SCIENTISTS

Victoria Peterson, PhD

Postdoctoral fellow

Instituto de Matemática Aplicada del Litoral, UNL-CONICET 

Ashley Walton, PhD

Postdoctoral fellow

Cognitive Science Program, Dartmouth College

Nathan Sisterson, MD

Neurosurgery Resident, MGH

CLINICAL SUPPORT
Nora Daly, MSHS, PA-C

Physician Assistant

MGH Functional Neurosurgery

AREAS OF INVESTIGATION

PAGes

under

construction

Basal Ganglia-Basal Ganglia-Cortical Dynamics in Human Behavior 

Intraoperatively, we collect task-based, simultaneously recorded cortical ECoG and subcortical MER/LFP data to study interactions between the cortex and basal ganglia that code for specific components of motor action.

 

BRAIN Initiative-funded Project:

Closed-Loop DBS for Parkinson's Disease

BRAIN Initiative-funded Project:

Brain Stimulation for Epilepsy

The lab's initial work involved sensing-enabled DBS (PC+S and RC+S) in a nonhuman primate with idiopathic epilepsy. Subsequently, in order to better understand data recorded during responsive neurostimulation in our epilepsy patients, we built BRAINStim, a platform for Biophysically Rational Analysis and Informed Stimulation.

 

Thier Building, 4th floor

Massachusetts General Hospital

50 Blossom St.
Boston, MA 02114