Basal Ganglia-Cortical Dynamics in Human Behavior 

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Intraoperatively, we collect simultaneously recorded cortical ECoG, subcortical MER/LFP, and behavioral data to study interactions between the cortex and basal ganglia that encode specific components of motor control.

 

STN and STN-Cortical Coding of Speech Production

BRAIN Initiative

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Cortical-Basal Ganglia Speech Networks

BRAIN Initiative

 

Deep Neural Network Approaches for Closed-loop DBS

CRNCS in collaboration with ICNeuromodulation Neumann Group - Charité Universitätsmedizin Berlin

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Closed-Loop Brain Stimulation for Epilepsy

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The lab's initial work in brain stimulation for epilepsy involved sensing-enabled DBS (PC+S and RC+S) in a nonhuman primate with idiopathic epilepsy. Subsequently, in order to better understand data recorded during responsive neurostimulation in our epilepsy patients, we built BRAINStim, a platform for Biophysically Rational Analysis and Informed Stimulation.

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Computational Neuroscience of Language Processing 

In this project led by Ev Fedorenko, we are collaborating to study neural responses to language stimuli using intracranial recordings, in combination with the recent advances in computational neuroscience and machine learning, in a quest to understand human linguistic ability.

 

Mapping the Olfactory Perception Network

With funding from Lawnboy Ventures, we are using intracranial LFP recordings to map the electrophysiological correlates of odor perception, with a goal of defining network signatures of odor categories that can be recapitulated via electrical stimulation. The goal of this project is to development an olfactory prosthesis for patients with anosmia. 

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Clinical Innovation in Functional Neurosurgery​

The lab's resources, including surgical databases, are leveraged to innovate and advance neurosurgical strategies and technical approaches to better treat epilepsy, movement disorders, and other brain diseases.