SetPoint VNS for Rheumatoid Arthritis

Vagus nerve stimulation for rheumatoid arthritis.

SetPoint is an implanted vagus nerve stimulator for rheumatoid arthritis (RA). The FDA approved it in July 2025 for adults with moderately to severely active RA who have had an inadequate response, loss of response, or intolerance to one or more biologic or targeted synthetic DMARDs. The device delivers one minute of stimulation each day and is recharged for a few minutes once a week.

Dr. Pranav Nanda and Dr. Mark Richardson perform the implant procedure. Dr. Richardson was the national surgical principal investigator for RESET-RA, the randomized pivotal trial of 242 implanted patients that led to approval.

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Who can use this section.

Patients can refer themselves. Rheumatologists can refer a patient with the same form. Self-referrals and physician referrals go to the same intake queue.

In this section.

Patient guide. How SetPoint works, what the operation involves, what to expect from therapy, and the risks.

For rheumatologists. The indication, RESET-RA results, safety data, patient selection, and how to refer.

Referral form. One form for patients and referring clinicians.